The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EDNRBBA-20-REGO | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-REGR | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-ORGR | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-GOGR | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-GRRE | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-GROR | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-GRGO | 20 (40 μL) | 200 μL |
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| EDNRBBA-20-AQOR | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Symbol : EDNRB
Gene Name : Endothelin receptor type B
Chromosome : CHR 13: 779,755,28-778,954,80
Locus : 13q22.3
Alt. Genes : SUGP2
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