This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TPP1BA-20-REGO | 20 (40 μL) | 200 μL |
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| TPP1BA-20-REGR | 20 (40 μL) | 200 μL |
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| TPP1BA-20-ORGR | 20 (40 μL) | 200 μL |
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| TPP1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| TPP1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| TPP1BA-20-GROR | 20 (40 μL) | 200 μL |
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| TPP1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| TPP1BA-20-AQOR | 20 (40 μL) | 200 μL |
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This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Gene Symbol : TPP1
Gene Name : Tripeptidyl peptidase 1
Chromosome : CHR 11: 661,946,0-661,276,5
Locus : 11p15.4
Alt. Genes : ENAM
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