| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| A2M-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| A2M-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Symbol : A2M
Gene Name : Alpha-2-macroglobulin
Chromosome : CHR 12: 911,596,1-906,770,7
Locus : 12p13.31
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Symbol : ARFGEF2
Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 2
Chromosome : CHR 20: 489,217,20-490,366,92
Locus : 20q13.13
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