| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABL1-BCR-20-RERE | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-REOR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-REGO | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-REGR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-REAQ | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-ORRE | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-OROR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-ORGO | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-ORGR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GORE | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GOOR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GOGO | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GOGR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GRRE | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GROR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GRGO | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GRGR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-AQRE | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-AQOR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-AQGO | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-AQGR | 20 (40 μL) | 200 μL |
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| ABL1-BCR-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Symbol : ABL1
Gene Name : ABL proto-oncogene 1, non-receptor tyrosine kinase
Chromosome : CHR 9: 130,713,880-130,887,674
Locus : 9q34.12
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : BCR
Gene Name : BCR, RhoGEF and GTPase activating protein
Chromosome : CHR 22: 231,803,64-233,180,36
Locus : 22q11.23
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