| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ABL1-PRDM12-20-RERE | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-REOR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-REGO | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-REGR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-REAQ | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-ORRE | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-OROR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-ORGO | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-ORGR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GORE | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GOOR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GOGO | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GOGR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GRRE | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GROR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GRGO | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GRGR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-AQRE | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-AQOR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-AQGO | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-AQGR | 20 (40 μL) | 200 μL |
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| ABL1-PRDM12-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Symbol : ABL1
Gene Name : ABL proto-oncogene 1, non-receptor tyrosine kinase
Chromosome : CHR 9: 130,713,880-130,887,674
Locus : 9q34.12
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017]
Gene Symbol : PRDM12
Gene Name : PR/SET domain 12
Chromosome : CHR 9: 130,664,593-130,682,996
Locus : 9q34.12
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