ABL1 Summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

ABL1 Details

Gene Symbol : ABL1

Gene Name : ABL proto-oncogene 1, non-receptor tyrosine kinase

Chromosome : CHR 9: 130,713,880-130,887,674

Locus : 9q34.12

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SLC38A10 Details

Gene Symbol : SLC38A10

Gene Name : Solute carrier family 38 member 10

Chromosome : CHR 17: 812,954,32-812,448,10

Locus : 17q25.3

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