ACSL3 Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ACSL3 Details

Gene Symbol : ACSL3

Gene Name : Acyl-CoA synthetase long chain family member 3

Chromosome : CHR 2: 222,860,983-222,944,623

Locus : 2q36.1

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SGPP2 Summary

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

SGPP2 Details

Gene Symbol : SGPP2

Gene Name : Sphingosine-1-phosphate phosphatase 2

Chromosome : CHR 2: 222,424,051-222,562,621

Locus : 2q36.1

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