| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ADAM17-YWHAQ-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
Gene Symbol : ADAM17
Gene Name : ADAM metallopeptidase domain 17
Chromosome : CHR 2: 955,581,9-948,848,5
Locus : 2p25.1
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Gene Symbol : YWHAQ
Gene Name : Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Chromosome : CHR 2: 963,105,4-958,396,6
Locus : 2p25.1
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