| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAMTS17-NCF4-20-RERE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-OROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GORE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-NCF4-20-AQAQ | 20 (40 μL) | 200 μL |
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The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Symbol : NCF4
Gene Name : Neutrophil cytosolic factor 4
Chromosome : CHR 22: 368,609,87-368,780,16
Locus : 22q12.3
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Gene Symbol : ADAMTS17
Gene Name : ADAM metallopeptidase with thrombospondin type 1 motif 17
Chromosome : CHR 15: 100,342,923-999,714,37
Locus : 15q26.3
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