SKU | Test Kits | Buffer | Dye Color | Order Now |
---|---|---|---|---|
AFF1-WWOX-20-RERE | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-REOR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-REGO | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-REGR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-REAQ | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-ORRE | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-OROR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-ORGO | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-ORGR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-ORAQ | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GORE | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GOOR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GOGO | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GOGR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GOAQ | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GRRE | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GROR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GRGO | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GRGR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-GRAQ | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-AQRE | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-AQOR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-AQGO | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-AQGR | 20 (40 μL) | 200 μL | Request Pricing | |
AFF1-WWOX-20-AQAQ | 20 (40 μL) | 200 μL | Request Pricing |
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Symbol : AFF1
Gene Name : AF4/FMR2 family member 1
Chromosome : CHR 4: 869,350,01-871,410,53
Locus : 4q21.3-q22.1
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Symbol : WWOX
Gene Name : WW domain containing oxidoreductase
Chromosome : CHR 16: 780,994,12-792,126,66
Locus : 16q23.1-q23.2
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