AFF1-WWOX Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
AFF1-WWOX-20-RERE 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-REOR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-REGO 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-REGR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-OROR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GORE 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GROR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
AFF1-WWOX-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

AFF1 Summary

This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

AFF1 Details

Gene Symbol : AFF1

Gene Name : AF4/FMR2 family member 1

Chromosome : CHR 4: 869,350,01-871,410,53

Locus : 4q21.3-q22.1


WWOX Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

WWOX Details

Gene Symbol : WWOX

Gene Name : WW domain containing oxidoreductase

Chromosome : CHR 16: 780,994,12-792,126,66

Locus : 16q23.1-q23.2


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