AFF3 Summary

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

AFF3 Details

Gene Symbol : AFF3

Gene Name : AF4/FMR2 family member 3

Chromosome : CHR 2: 100,142,582-995,458,60

Locus : 2q11.2

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NPAS2 Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

NPAS2 Details

Gene Symbol : NPAS2

Gene Name : Neuronal PAS domain protein 2

Chromosome : CHR 2: 100,820,150-100,996,828

Locus : 2q11.2

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