ATG4B Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ATG4B Details

Gene Symbol : ATG4B

Gene Name : Autophagy related 4B cysteine peptidase

Chromosome : CHR 2: 241,637,611-241,673,856

Locus : 2q37.3

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AGAP1 Summary

This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

AGAP1 Details

Gene Symbol : AGAP1

Gene Name : ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Chromosome : CHR 2: 235,494,088-236,131,799

Locus : 2q37.2

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