EIF2AK2 Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

EIF2AK2 Details

Gene Symbol : EIF2AK2

Gene Name : Eukaryotic translation initiation factor 2 alpha kinase 2

Chromosome : CHR 2: 371,570,64-370,992,09

Locus : 2p22.2

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AGR2 Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]

AGR2 Details

Gene Symbol : AGR2

Gene Name : Anterior gradient 2, protein disulphide isomerase family member

Chromosome : CHR 7: 168,051,13-167,918,10

Locus : 7p21.1

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