| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AKAP13-RET-20-RERE | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-REOR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-REGO | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-REGR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-REAQ | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-ORRE | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-OROR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-ORGO | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-ORGR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GORE | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GOOR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GOGO | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GOGR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GRRE | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GROR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GRGO | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GRGR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-AQRE | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-AQOR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-AQGO | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-AQGR | 20 (40 μL) | 200 μL |
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| AKAP13-RET-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Gene Symbol : RET
Gene Name : Ret proto-oncogene
Chromosome : CHR 10: 430,770,68-431,303,50
Locus : 10q11.21
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Symbol : AKAP13
Gene Name : A-kinase anchoring protein 13
Chromosome : CHR 15: 853,806,15-857,493,57
Locus : 15q25.3
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