AKT2 Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]

AKT2 Details

Gene Symbol : AKT2

Gene Name : AKT serine/threonine kinase 2

Chromosome : CHR 19: 402,855,30-402,303,16

Locus : 19q13.2

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ELK3 Summary

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ELK3 Details

Gene Symbol : ELK3

Gene Name : ELK3, ETS transcription factor

Chromosome : CHR 12: 961,943,81-962,698,34

Locus : 12q23.1

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