ANXA1 Summary

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

ANXA1 Details

Gene Symbol : ANXA1

Gene Name : Annexin A1

Chromosome : CHR 9: 731,517,30-731,703,92

Locus : 9q21.13

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TLN1 Summary

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

TLN1 Details

Gene Symbol : TLN1

Gene Name : Talin 1

Chromosome : CHR 9: 357,323,94-356,973,36

Locus : 9p13.3

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