AP2A2 Summary

The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]

AP2A2 Details

Gene Symbol : AP2A2

Gene Name : Adaptor related protein complex 2 alpha 2 subunit

Chromosome : CHR 11: 925,808-101,224,4

Locus : 11p15.5

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VPS26A Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

VPS26A Details

Gene Symbol : VPS26A

Gene Name : VPS26, retromer complex component A

Chromosome : CHR 10: 691,241,52-691,744,15

Locus : 10q22.1

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