| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AP2M1-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-ORGR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| AP2M1-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Gene Symbol : AP2M1
Gene Name : Adaptor related protein complex 2 mu 1 subunit
Chromosome : CHR 3: 184,174,845-184,184,090
Locus : 3q27.1
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Symbol : SEC63
Gene Name : SEC63 homolog, protein translocation regulator
Chromosome : CHR 6: 107,958,277-107,867,755
Locus : 6q21
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