APC Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

APC Details

Gene Symbol : APC

Gene Name : APC, WNT signaling pathway regulator

Chromosome : CHR 5: 112,707,504-112,846,238

Locus : 5q22.2

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REEP2 Summary

This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

REEP2 Details

Gene Symbol : REEP2

Gene Name : Receptor accessory protein 2

Chromosome : CHR 5: 138,439,000-138,446,968

Locus : 5q31.2

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