APOA2 Summary

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

APOA2 Details

Gene Symbol : APOA2

Gene Name : Apolipoprotein A2

Chromosome : CHR 1: 161,223,627-161,222,292

Locus : 1q23.3

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TYK2 Summary

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

TYK2 Details

Gene Symbol : TYK2

Gene Name : Tyrosine kinase 2

Chromosome : CHR 19: 103,805,71-103,505,27

Locus : 19p13.2

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