| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APPBP2-WISP2-20-RERE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-REAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-OROR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GORE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GROR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQRE | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQOR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQGO | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQGR | 20 (40 μL) | 200 μL |
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| APPBP2-WISP2-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
Gene Symbol : WISP2
Gene Name : WNT1 inducible signaling pathway protein 2
Chromosome : CHR 20: 447,142,03-447,280,40
Locus : 20q13.12
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Symbol : APPBP2
Gene Name : Amyloid beta precursor protein binding protein 2
Chromosome : CHR 17: 605,262,39-604,431,48
Locus : 17q23.2
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