PACSIN2 Summary

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PACSIN2 Details

Gene Symbol : PACSIN2

Gene Name : Protein kinase C and casein kinase substrate in neurons 2

Chromosome : CHR 22: 430,156,89-428,697,65

Locus : 22q13.2

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ARFGAP3 Summary

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

ARFGAP3 Details

Gene Symbol : ARFGAP3

Gene Name : ADP ribosylation factor GTPase activating protein 3

Chromosome : CHR 22: 428,574,01-427,965,25

Locus : 22q13.2

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