| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARFGEF1-SHC1-20-RERE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-OROR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GORE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GROR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Symbol : SHC1
Gene Name : SHC adaptor protein 1
Chromosome : CHR 1: 154,974,491-154,962,297
Locus : 1q21.3
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Gene Symbol : ARFGEF1
Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 1
Chromosome : CHR 8: 673,439,26-671,742,97
Locus : 8q13.2
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