FBXW2 Summary

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

FBXW2 Details

Gene Symbol : FBXW2

Gene Name : F-box and WD repeat domain containing 2

Chromosome : CHR 9: 120,793,470-120,756,975

Locus : 9q33.2

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ARHGAP10 Details

Gene Symbol : ARHGAP10

Gene Name : Rho GTPase activating protein 10

Chromosome : CHR 4: 147,732,062-148,072,780

Locus : 4q31.23

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