SMCP Summary

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

SMCP Details

Gene Symbol : SMCP

Gene Name : Sperm mitochondria associated cysteine rich protein

Chromosome : CHR 1: 152,878,321-152,885,046

Locus : 1q21.3

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ARHGEF11 Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ARHGEF11 Details

Gene Symbol : ARHGEF11

Gene Name : Rho guanine nucleotide exchange factor 11

Chromosome : CHR 1: 157,046,902-156,934,839

Locus : 1q23.1

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