ARHGEF12 Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

ARHGEF12 Details

Gene Symbol : ARHGEF12

Gene Name : Rho guanine nucleotide exchange factor 12

Chromosome : CHR 11: 120,336,275-120,489,935

Locus : 11q23.3

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POU2F3 Summary

This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

POU2F3 Details

Gene Symbol : POU2F3

Gene Name : POU class 2 homeobox 3

Chromosome : CHR 11: 120,236,639-120,319,943

Locus : 11q23.3

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