| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARHGEF7-PTEN-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGEF7-PTEN-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Gene Symbol : PTEN
Gene Name : Phosphatase and tensin homolog
Chromosome : CHR 10: 878,634,37-879,719,29
Locus : 10q23.31
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Gene Symbol : ARHGEF7
Gene Name : Rho guanine nucleotide exchange factor 7
Chromosome : CHR 13: 111,114,618-111,305,733
Locus : 13q34
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