| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARRB1-PICALM-20-RERE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-REAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-OROR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GORE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GROR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQRE | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQOR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQGO | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQGR | 20 (40 μL) | 200 μL |
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| ARRB1-PICALM-20-AQAQ | 20 (40 μL) | 200 μL |
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Gene Symbol : ARRB1
Gene Name : Arrestin beta 1
Chromosome : CHR 11: 753,518,30-752,601,21
Locus : 11q13.4
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Symbol : PICALM
Gene Name : Phosphatidylinositol binding clathrin assembly protein
Chromosome : CHR 11: 860,698,80-859,571,70
Locus : 11q14.2
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