ARRB1-PRCP Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ARRB1-PRCP-20-RERE 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-REOR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-OROR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GORE 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
ARRB1-PRCP-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

ARRB1 Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

ARRB1 Details

Gene Symbol : ARRB1

Gene Name : Arrestin beta 1

Chromosome : CHR 11: 753,518,30-752,601,21

Locus : 11q13.4


PRCP Summary

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PRCP Details

Gene Symbol : PRCP

Gene Name : Prolylcarboxypeptidase

Chromosome : CHR 11: 829,017,39-828,229,39

Locus : 11q14.1


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