TMPRSS2 Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS2 Details

Gene Symbol : TMPRSS2

Gene Name : Transmembrane protease, serine 2

Chromosome : CHR 21: 415,081,57-414,645,50

Locus : 21q22.3

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ATF7IP Summary

ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

ATF7IP Details

Gene Symbol : ATF7IP

Gene Name : Activating transcription factor 7 interacting protein

Chromosome : CHR 12: 143,656,31-145,029,34

Locus : 12p13.1

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