| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ATG4D-UHRF1-20-RERE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-OROR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GORE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GROR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| ATG4D-UHRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Gene Symbol : UHRF1
Gene Name : Ubiquitin like with PHD and ring finger domains 1
Chromosome : CHR 19: 490,307,9-496,215,3
Locus : 19p13.3
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Symbol : ATG4D
Gene Name : Autophagy related 4D cysteine peptidase
Chromosome : CHR 19: 105,438,93-105,534,22
Locus : 19p13.2
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