ATP6AP1 Summary

This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

ATP6AP1 Details

Gene Symbol : ATP6AP1

Gene Name : ATPase H+ transporting accessory protein 1

Chromosome : CHR X: 154,428,631-154,436,516

Locus : Xq28

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ARFGEF2 Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

ARFGEF2 Details

Gene Symbol : ARFGEF2

Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 2

Chromosome : CHR 20: 489,217,20-490,366,92

Locus : 20q13.13

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