The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| A2M-20-RE | 20 (40 μL) | 200 μL |  |
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| A2M-20-OR | 20 (40 μL) | 200 μL |  |
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| A2M-20-GO | 20 (40 μL) | 200 μL |  |
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| A2M-20-GR | 20 (40 μL) | 200 μL |  |
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| A2M-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Gene Symbol : A2M
Gene Name : Alpha-2-macroglobulin
Chromosome : CHR 12: 911,596,1-906,770,7
Locus : 12p13.31
Alt. Genes : PAK4
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