This element represents a locus control region (LCR) that can confer T cell-specific, copy number-dependent, position-independent expression on the CD2 gene in transgenic mice. It is located immediately downstream of the 3' terminal exon of the CD2 gene, and is characterized by three DNase I hypersensitive sites and a core enhancer region. This LCR and the enhancer sub-region have been used to drive T cell-specific expression of several heterologous genes in various vector systems, including retroviral and lentiviral vectors. A truncated version of the LCR has been shown to be heterochromatin-sensitive, and has thus been useful for studying chromatin-related processes, such as triplet-repeat-associated position effect variegation. [provided by RefSeq, Jan 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CD2-LCR-20-RE | 20 (40 μL) | 200 μL |  |
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| CD2-LCR-20-OR | 20 (40 μL) | 200 μL |  |
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| CD2-LCR-20-GO | 20 (40 μL) | 200 μL |  |
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| CD2-LCR-20-GR | 20 (40 μL) | 200 μL |  |
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| CD2-LCR-20-AQ | 20 (40 μL) | 200 μL |  |
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This element represents a locus control region (LCR) that can confer T cell-specific, copy number-dependent, position-independent expression on the CD2 gene in transgenic mice. It is located immediately downstream of the 3' terminal exon of the CD2 gene, and is characterized by three DNase I hypersensitive sites and a core enhancer region. This LCR and the enhancer sub-region have been used to drive T cell-specific expression of several heterologous genes in various vector systems, including retroviral and lentiviral vectors. A truncated version of the LCR has been shown to be heterochromatin-sensitive, and has thus been useful for studying chromatin-related processes, such as triplet-repeat-associated position effect variegation. [provided by RefSeq, Jan 2016]
Gene Symbol : CD2-LCR
Gene Name : CD2 locus control region
Chromosome : CHR 1: 0-0
Locus : 1p13.1
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